| 主权项 |
1. A compound of formula (I): in which:represents a group selected from:group;
wherein * indicates the point of attachment of said group with the rest of the molecule; and represents a group selected from:
R1-C≡C—*, R1-CH═CH—*, R1-CH2—CH2—*, or group; wherein * indicates the point of attachment of said group with the rest of the molecule; and R1 represents a linear C1-C6-alkyl-, a branched C3-C6-alkyl-, or a C3-C6-cycloalkyl group which is optionally substituted, one or more times, independently from each other, with a substituent selected from: a halogen atom, a —CN, C1-C6-alkyl-, C1-C6-haloalkyl-, C2-C6-alkenyl-, C2-C6-alkynyl-, C3-C10-cycloalkyl-, aryl-optionally substituted one or more times, independently from each other, with an R substituent; —C(═O)NH2, —C(═O)N(H)R′, —C(═O)N(R′)R″, C(═O)OH, —C(═O)OR′, —NH2, —NHR′, —N(R′)R″, —N(H)C(═O)R′, —N(R′)C(═O)R′, —N(H)S(═O)R′, —N(R′)S(═O)R′, —N(H)S(═O)2R′, —N(R′)S(═O)2R′, —N═S(═O)(R′)R″, —OH, C1-C6-alkoxy-, C1-C6-haloalkoxy-, —OC(═O)R′, —OC(═O)NH2, —OC(═O)NHR′, —OC(═O)N(R′)R″, —SH, C1-C6-alkyl-S—, —S(═O)R′, —S(═O)2R′, —S(═O)2NH2, —S(═O)2NHR′, —S(═O)2N(R′)R″ group; R2 represents a hydrogen atom; R3 represents a substituent selected from: a halogen atom, a —CN, C1-C6-alkyl-, C1-C6-haloalkyl-, C2-C6-alkenyl-, C2-C6-alkynyl-, —C(═O)R′, —C(═O)NH2, —C(═O)N(H)R′, —C(═O)N(R′)R″, —NH2, —NHR′, —N(R′)R″, —N(H)C(═O)R′, —N(R′)C(═O)R′, —N(H)C(═O)NH2, —N(H)C(═O)NHR′, —N(H)C(═O)N(R′)R″, —N(R′)C(═O)NH2, —N(R′)C(═O)NHR′, —N(R′)C(═O)N(R′)R″, —N(H)C(═O)OR′, —N(R′)C(═O)OR′, —NO2, —N(H)S(═O)R′, —N(R′)S(═O)R′, —N(H)S(═O)2R′, —N(R′)S(═O)2R′, —N═S(═O)(R′)R″, —OH, C1-C6-alkoxy-, C3-C6-cycloalkyl-C1-C6-alkoxy-, C1-C6-haloalkoxy-, —OC(═O)R′, —SH, C1-C6-alkyl-S—, —S(═O)R′, —S(═O)2R′, —S(═O)2NH2, —S(═O)2NHR′, —S(═O)2N(R′)R″, —S(═O)(═NR′)R″ group; or a 4- to 7-membered nitrogen atom containing heterocycloalkyl group which is optionally substituted one or more times, independently from each other with a C1-C6-alkyl-group, said heterocycloalkyl group being attached to the rest of the molecule via a nitrogen ring atom of the heterocycloalkyl group; and said 6- to 10-membered cyclic amine group optionally containing one further heteroatom selected from the group consisting of O, N and S; R4 represents a substituent selected from: a hydrogen atom, a halogen atom, a —CN, C1-C6-alkyl-, C1-C6-haloalkyl-, C2-C6-alkenyl-, C2-C6-alkynyl-, C3-C10-cycloalkyl-, 4- to 10-membered heterocycloalkyl-, aryl-optionally substituted one or more times, independently from each other, with an R substituent; heteroaryl-optionally substituted one or more times, independently from each other, with an R substituent —C(═O)NH2, —C(═O)N(H)R′, —C(═O)N(R′)R″, —C(═O)OR′, —NH2, —NHR′, —N(R′)R″, —N(H)C(═O)R′, —N(R′)C(═O)R′, —N(H)C(═O)NH2, —N(H)C(═O)NHR′, —N(H)C(═O)N(R′)R″, —N(R′)C(═O)NH2, —N(R′)C(═O)NHR′, —N(R′)C(═O)N(R′)R″, —N(H)C(═O)OR′, —N(R′)C(═O)OR′, —NO2, —N(H)S(═O)R′, —N(R′)S(═O)R′, —N(H)S(═O)2R′, —N(R′)S(═O)2R′, —N═S(═O)(R′)R″, —OH, C1-C6-alkoxy-, C1-C6-haloalkoxy-, —OC(═O)R′, —OC(═O)NH2, —OC(═O)NHR′, —OC(═O)N(R′)R″, —SH, C1-C6-alkyl-S—, —S(═O)R′, —S(═O)2R′, —S(═O)2NH2, —S(═O)2NHR′, —S(═O)2N(R′)R″, —S(═O)(═NR′)R″ group; R5 represents a substituent selected from a hydrogen atom or C1-C6-alkyl-;
or:R1 and R5 together with the nitrogen atom to which they are attached form a 4-, 5-, 6- or 7-membered heterocycloalkyl group, which is optionally substituted one or more times, independently from each other with a substituent selected from:
a halogen atom, a —CN, C1-C6-alkyl-, C1-C6-haloalkyl-, C2-C6-alkenyl-, C2-C6-alkynyl-, C3-C10-cycloalkyl-, aryl-optionally substituted one or more times, independently from each other, with an R substituent; heteroaryl-optionally substituted one or more times, independently from each other, with an R substituent; —C(═O)NH2, —C(═O)N(H)R′, —C(═O)N(R′)R″, —C(═O)OH, —C(═O)OR′, —NH2, —NHR′, —N(R′)R″, —N(H)C(═O)R′, —N(R′)C(═O)R′, —N(H)S(═O)R′, —N(R′)S(═O)R′, —N(H)S(═O)2R′, —N(R′)S(═O)2R′, —N═S(═O)(R′)R″, —OH, C1-C6-alkoxy-, C1-C6-haloalkoxy-, —OC(═O)R′, —OC(═O)NH2, —OC(═O)NHR′, —OC(═O)N(R′)R″, —SH, C1-C6-alkyl-S—, —S(═O)R′, —S(═O)2R′, —S(═O)2NH2, —S(═O)2NHR′, —S(═O)2N(R′)R″ group;said 6- or 7-membered heterocycloalkyl group optionally containing one further heteroatom selected from the group consisting of O, N and S; R represents a substituent selected from: a halogen atom, a —CN, C1-C6-alkyl-, C1-C6-haloalkyl-, C2-C6-alkenyl-, C2-C6-alkynyl-, C3-C10-cycloalkyl-, 4- to 10-membered heterocycloalkyl-, aryl-, heteroaryl-, —C(═O)R′, —C(═O)NH2, —C(═O)N(H)R′, —C(═O)N(R′)R″, —C(═O)OR′, —NH2, —NHR′, —N(R′)R″, —N(H)C(═O)R′, —N(R′)C(═O)R′, —N(H)C(═O)NH2, —N(H)C(═O)NHR′, —N(H)C(═O)N(R′)R″, —N(R′)C(═O)NH2, —N(R′)C(═O)NHR′, —N(R′)C(═O)N(R′)R″, —N(H)C(═O)OR′, —N(R′)C(═O)OR′, —NO2, —N(H)S(═O)R′, —N(R′)S(═O)R′, —N(H)S(═O)2R′, —N(R′)S(═O)2R′, —N═S(═O)(R′)R″, —OH, C1-C6-alkoxy-, C1-C6-haloalkoxy-, —OC(═O)R′, —OC(═O)NH2, —OC(═O)NHR′, —OC(═O)N(R′)R″, —SH, C1-C6-alkyl-S—, —S(═O)R′, —S(═O)2R′, —S(═O)2NH2, —S(═O)2NHR′, —S(═O)2N(R′)R″, —S(═O)(═NR′)R″ group; R′ and R″ represent, independently from each other, a substituent selected from: a C1-C6-alkyl-, C3-C10-cycloalkyl-, C1-C6-haloalkyl-, C1-C3-alkoxy-C2-C6-alkyl-group; n represents an integer of 0, 1, 2, 3, 4 or 5 when represents a:group;or
n represents an integer of 0, 1, 2, 3 or 4 whenrepresents a group selected from:group;
or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same. |
