ION-EXCHANGE COMPOSITION COMPRISING A COMPLEX OF SUPPORT PARTICLES, DISPERSANT, AND ELECTROSTATICALLY BOUND LAYERING PARTICLES

摘要

An ion-exchange composition suitable for use in ion exchange chromatography, comprising neutral vinyl polymer support particles irreversibly bound to a dispersant having ionizable sites which are un-ionized at a neutral pH and which are ionized under highly acidic or highly basic conditions, and fine layering particles functionalized with ion-exchanging sites on the surfaces thereof. A portion of the ionizable sites are ionized and bound electrostatically to a portion of the fine layering particles ion-exchanging sites, producing a support particle-dispersant-fine layering particle complex.

主权项

1. A method of producing an ion-exchange composition suitable for use in ion exchange chromatography, said method comprising the steps of:
(a) forming a first complex of neutral vinyl polymer support particles irreversibly bound to a dispersant, said dispersant having ionizable sites which are un-ionized at a neutral pH and which are ionized under highly basic or highly acidic conditions, (b) forming a mixture of said first complex with an aqueous slurry of fine layering particles, functionalized with ion-exchanging sites on the surfaces of said fine layering particles, at said highly basic or highly acidic conditions so that said dispersant includes said ionized sites, and (c) electrostatically binding said dispersant ionized sites to a portion of said fine particle ion-exchanging sites to produce a support particle-dispersant-fine layering particle complex.