| 摘要 |
The present invention discloses an alcoholic extract from the leaves of Vitex nigundo which when added to antibiotics, not only increases their activity but also helps to overcome antibiotic resistance in bacteria. The extract has distinctive analytical fingerprints as given in Fig. 1 and Fig. 2 and the marker compounds in the extract are vitexin and quercetin. Some of the phytocompounds present in the extract are derivatives of vitexin and quercetin. Extract of invention involves taking fresh leaves, washing and sterilizing them and then drying the leaves at 37°C followed by powdering, extraction with alcohol and purification on silica gel column. Significant enhancement of activity of the synthetic antibiotics, such as ciprofloxacin and amoxyclav was observed against bacteria viz. S. aureus, E. coli, S. typhi and P. aeruginosa, when extract of present invention was used along with the antibiotics. |
