| 发明名称 |
PHARMACEUTICAL COMPOSITION WITH IMPROVED STORAGE STABILITY AND METHOD FOR PREPARING THE SAME |
| 摘要 |
A pharmaceutical composition containing a specific related compound within a specified limit and a method for preparing the same are provided. |
| 申请公布号 |
US2017028068(A1) |
申请公布日期 |
2017.02.02 |
| 申请号 |
US201615222157 |
申请日期 |
2016.07.28 |
| 申请人 |
SAMYANG BIOPHARMACEUTICALS CORPORATION |
发明人 |
KIM Bong Oh;MIN Bum Chan;KIM Ji Yeong;KIM Hye Rim;SEO Min Hyo;LEE Sa Won;YI Yil Woong;CHO Joong Woong;CHOI In Ja |
| 分类号 |
A61K47/34;A61K31/337;A61K47/32;A61K9/107 |
主分类号 |
A61K47/34 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polymeric micelle pharmaceutical composition, comprising:
a purified amphiphilic block copolymer comprising a hydrophilic block (A) and a hydrophobic block (B), and one or more poorly water-soluble drugs selected from the group consisting of paclitaxel and docetaxel, wherein the pharmaceutical composition contains, when stored at 40° C. for 6 months, a related compound represented by the following Formula 1 in an amount of less than 0.58 part by weight, based on 100 parts by weight of the initial amount of the poorly water-soluble drug: wherein R1 is H or COCH3, and R2 is phenyl or O(CH3)3. |
| 地址 |
Seoul KR |
