Use of a Composition Comprising a Flavonol, A Flavonoid, and a Fatty Acid in the Treatment of Oxidative Injuries Due to Mitochondrial Dysfunction

摘要

Compositions comprising a flavan-3-ol, a flavonoid, and a fatty acid have been demonstrated to mitigate the oxidative damage arising from mitochondrial dysfunction. In preferred embodiments, the composition comprises epicatechin, quercetin, and cicosapentaenoic acid (EPA) ethyl ester. The disorders to be treated include neurodegenerative disorders such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), Alzheimer's disease, and multiple sclerosis (MS); neurological damage due to stroke; and ototoxicity arising from chemotherapy with cisplatin.

主权项

1. A method for treating, prophylactically treating, preventing or reducing the severity of oxidative injury resulting from mitochondrial dysfunction comprising administering to an individual in need of such treatment an effective amount of a composition comprising a flavan-3-ol, a flavonoid and a fatty acid.