| 发明名称 |
1,3,8-TRIAZASPIRO[4,5]DECAN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF ORL-1 RECEPTOR MEDIATED DISORDERS |
| 摘要 |
The present invention is directed to novel 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formulawherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, substance abuse, neuropathic pain, acute pain, migraine, asthma, cough and for improved cognition. |
| 申请公布号 |
EP1392687(B1) |
申请公布日期 |
2017.02.01 |
| 申请号 |
EP20020721678 |
申请日期 |
2002.04.05 |
| 申请人 |
Janssen Pharmaceuticals, Inc. |
发明人 |
JORDAN, Alfonzo;PAN, Kevin;REITZ, Allen, B. |
| 分类号 |
C07D471/10;A61K31/435;A61K31/438;A61P11/06;A61P11/14;A61P25/00;A61P25/06;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P43/00 |
主分类号 |
C07D471/10 |
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