THERAPEUTICS OLIGONUCLEOTIDES

摘要

The present invention relates to oligonucleotides that hybridize to small RNAs. In particular the oligonucleotide comprises one of the following sequences: (TTAGGG) SEQ ID No. 1, (TAGGGT) SEQ ID No. 2, (AGGGTT) SEQ ID No. 3, (GGGTTA) SEQ ID No. 4, (GGTTAG) SEQ ID No. 5 or (GTTAGG) SEQ ID No. 6 or a complementary sequence thereof or a fragment or a variant thereof for use in the treatment and/or prevention of a disease characterized by alternative lengthening of telomeres or a telomere syndrome and relative pharmaceutical compositions.