发明名称 |
METHODS AND COMPOSITIONS FOR SPECIFIC MODULATION OF MCL-1 |
摘要 |
A series of stapled BCL-2 family peptide helices were identified as able to target the survival protein MCL-1 with high affinity and a subset with unprecedented selectivity. Agents and methods for selective pharmacologic neutralization of MCL-1 are provided for drug discovery and therapeutic uses, including use in overcoming the apoptotic resistance of cancer and other diseases associated with impaired cell death. |
申请公布号 |
EP3124494(A2) |
申请公布日期 |
2017.02.01 |
申请号 |
EP20160173528 |
申请日期 |
2009.12.09 |
申请人 |
Dana-Farber Cancer Institute, Inc. |
发明人 |
Walensky, Loren, D.;Stewart, Michelle, L. |
分类号 |
C07K14/47;A61K38/17;A61P35/00 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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