3-PHENYL-7-HYDROXY-ISOCOUMARINS AS MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) INHIBITORS

摘要

A compound of the following formula or a pharmaceutically acceptable salt or hydrate thereof: wherein R1 and R4 are each independently selected from hydrogen and a substituent provided that at least one of R1 and R4 is a substituent; R2 and R3are each independently selected from hydrogen and a substituent; m is 0 to 3; n is 0 to 3. Preferably, R1 is selected from Me and hydrogen, R4 is selected from Me and hydrogen, m is 0, n is either 0 or 1 and when n is 1, R3 is selected from 6-Me, -6-OH and 6-OMe. These compounds are MIF inhibitors, thus compositions comprising said inhibitors are useful for treating or preventing diseases associated with MIF such as various cancers, particularly lung cancer.