Bone matrix compositions having nanoscale textured surfaces

摘要

Bone matrix compositions having nanoscale textured surfaces and methods for their production are provided. In some embodiments, bone matrix is prepared for implantation and retains nanoscale textured surfaces. In other embodiments, nanostructures are imparted to bone matrix wherein collagen fibrils on the surface of the bone matrix have been compromised, thus imparting a nanoscale textured surface to the bone matrix. Generally, these methods may be applied to mineralized or demineralized bone including partially or surface demineralized bone.

主权项

1. A demineralized bone matrix composition comprising lyophilized demineralized bone particles comprising an imparted nanoscale textured surface comprising collagen nanofibers electrospun onto the demineralized bone particles, wherein the imparted surface includes at least 60% non-denatured collagen, wherein the composition has less than about 15% moisture content, wherein the nanoscale textured surface comprises nanostructures each having a length ranging from approximately 40 nm to approximately 600 nm, the nanostructures comprising nanofibers, and the demineralized bone matrix composition further comprising a hydrogel carrier.