| 摘要 |
The present invention relates to a process for the preparation of estra-1,3,5(10)-trien-3,15±,16±,17²-tetraol (estetrol), via a silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10),16-tetraene, wherein A is a protecting group and B is €•Si(R 2 ) 3 . The invention further relates to a process for the synthesis of 3-A-oxy-estra-1,3,5(10),15-tetraen-17-one, wherein A is a protecting group, via said silyl enol ether derivative. |
