Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections

摘要

This invention relates to thieno[3,2-d]pyrimidines derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

主权项

1. A compound of formula (I)or a pharmaceutically acceptable salt, tautomer(s), stereo-isomeric form, or solvate thereof, wherein
R1 is selected from the group consisting of hydrogen, halogen, —CH3 and —CF3; R2 is selected from the group consisting of hydrogen, halogen, C1-6 alkyl and C3-6 cycloalkyl; R3 is C1-8 alkyl optionally substituted by one or more substituents independently selected from the group consisting of aryl, aryloxy, halogen, hydroxyl, alkylamino, dialkylamino, C1-6 alkenyl, C1-6 alkoxy, —CO2H, —CO2C1-6 alkyl, —CO2NH2, —CN, —SO2NHC1-3alkyl, —NHSO2C1-3alkyl, —NH(SO2)NH2, and —SO2N(H)(COC1-6 alkyl; or R3 is an alkylaryl optionally substituted by one or more substituents independently selected from the group consisting of aryl, aryloxy, halogen, alkylamino, dialkylamino, C1-6 alkyl, C1-6 alkenyl, C1-6 alkoxy, —CO2H, —CO2C1-6 alkyl, —CO2NH2, —CN, —SO2NHC1-3alkyl, —NHSO2C1-3alkyl, —NH(SO2)NH2, and —C(O)NHSO2C1-3alkyl.