| 主权项 |
1. A method for inhibiting angiogenesis comprising administering to a subject an anti-c-Met antibody or an antigen-binding fragment thereof, and an anti-Ang-2 antibody or an antigen-binding fragment thereof, in combination simultaneously or sequentially, wherein the anti-c-Met antibody or the antigen-binding fragment thereof comprises a heavy chain variable region comprising a CDR-H1, a CDR-H2, and a CDR-H3, and a light chain variable region comprising a CDR-L1, a CDR-L2, and a CDR-L3, and wherein:
the CDR-H1 has the amino acid sequence of SEQ ID NO: 1, the CDR-H2 has the amino acid sequence of SEQ ID NO: 2, the CDR-H3 has the amino acid sequence of SEQ ID NO: 3, the CDR-L1 has the amino acid sequence of SEQ ID NO: 10, the CDR-L2 has the amino acid sequence of SEQ ID NO: 11, andthe CDR-L3 has the amino acid sequence of SEQ ID NO: 13,
and wherein the anti-Ang-2 antibody or the antigen-binding fragment thereof comprises: a CDR-H1 having the amino acid sequence of SEQ ID NO: 109, a CDR-H2 having the amino acid sequence of SEQ ID NO: 117, and a CDR-H3 having the amino acid sequence of SEQ ID NO: 125, a CDR-L1 having the amino acid sequence of SEQ ID NO: 133, a CDR-L2 having the amino acid sequence of SEQ ID NOs: 141, and a CDR-L3 having the amino acid sequence of SEQ ID NO: 149; a CDR-H1 having the amino acid sequence of SEQ ID NO: 110, a CDR-H2 having the amino acid sequence of SEQ ID NO: 118, a CDR-H3 having the amino acid sequence of SEQ ID NO: 126, a CDR-L1 having the amino acid sequence of SEQ ID NO: 134, a CDR-L2 having the amino acid sequence of SEQ ID NO: 142, and a CDR-L3 having the n amino acid sequence of SEQ ID NO: 150; a CDR-H1 having the amino acid sequence of SEQ ID NO: 111, a CDR-H2 having the amino acid sequence of SEQ ID NO: 119, a CDR-H3 having the amino acid sequence of SEQ ID NO: 127, a CDR-L1 having the amino acid sequence of SEQ ID NO: 135, a CDR-L2 having the amino acid sequence of SEQ ID NO: 143, and a CDR-L3 having the amino acid sequence of SEQ ID NO: 151; a CDR-H1 having the amino acid sequence of SEQ ID NO: 112, a CDR-H2 having the amino acid sequence of SEQ ID NO: 120, a CDR-H3 having the amino acid sequence of SEQ ID NO: 128, a CDR-L1 having the amino acid sequence of SEQ ID NO: 136, a CDR-L2 having the amino acid sequence of SEQ ID NO: 144, and a CDR-L3 having the amino acid sequence of SEQ ID NO: 152; a CDR-H1 having the amino acid sequence of SEQ ID NO: 113, a CDR-H2 having the amino acid sequence of SEQ ID NO: 121, a CDR-H3 having the amino acid sequence of SEQ ID NO: 129, a CDR-L1 having the amino acid sequence of SEQ ID NO: 137, a CDR-L2 having the amino acid sequence of SEQ ID NO: 145, and a CDR-L3 having the amino acid sequence of SEQ ID NO: 153; a CDR-H1 having the amino acid sequence of SEQ ID NO: 114, a CDR-H2 having the amino acid sequence of SEQ ID NO: 122, a CDR-H3 having the amino acid sequence of SEQ ID NO: 130, a CDR-L1 having the amino acid sequence of SEQ ID NO: 138, a CDR-L2 having the amino acid sequence of SEQ ID NO: 146, and a CDR-L3 having the amino acid sequence of SEQ ID NO: 154; a CDR-H1 having the amino acid sequence of SEQ ID NO: 115, a CDR-H2 having the amino acid sequence of SEQ ID NO: 123, a CDR-H3 having the amino acid sequence of SEQ ID NO: 131, a CDR-L1 having the amino acid sequence of SEQ ID NO: 139, a CDR-L2 having the amino acid sequence of SEQ ID NO: 147, and a CDR-L3 having the amino acid sequence of SEQ ID NO: 155; or a CDR-H1 having the amino acid sequence of SEQ ID NO: 116, a CDR-H2 having the amino acid sequence of SEQ ID NO: 124, a CDR-H3 having the amino acid sequence of SEQ ID NO: 132, a CDR-L1 having the amino acid sequence of SEQ ID NO: 140, a CDR-L2 having the amino acid sequence of SEQ ID NO: 148, and a CDR-L3 having the amino acid sequence of SEQ ID NO: 156. |
