| 主权项 |
1. A compound having Formula (I): or a stereoisomer, a geometric isomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein R is wherein each X and X1a is independently O, S, S(═O), S(═O)2 or NRa; X1b is O, S, S(═O), or S(═O)2; X1c is S, S(═O) or S(═O)2; each Y, Y1, and Y2 is independently O, S, S(═O), S(═O)2, NRa or CRbRb′; Y1a is O, S, S(═O), S(═O)2, or CRbRb′; each Y3 is independently CRb″ or N; wherein each Ra is independently H, D or C1-3 alkyl; each Rb, Rb′ and Rb″ is independently H, D, F, Cl, Br, I, —OH, —NO2, —NH2, —CN, C1-3 alkyl, C1-3 alkoxy or C1-3 alkylamino; each R7 is independently H, D, F, Cl, Br, I, —OH, —SH, —NO2, —NH2, —CN, —COOH, C1-6 alkyl, C1-6 heteroalkyl, C1-6 alkylamino, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C2-10 heterocyclyl, C6-10 aryl, C6-10 aryl-C1-6-alkyl, C6-10 aryloxy, C6-10 aryl-C1-6-alkoxy or C1-9 heteroaryl; each d is independently 0, 1, 2, 3, 4 or 5; e is 0, 1, 2, or 3; f is 0 or 1; L is a bond, O or S; R1 is H, D, F, Cl, Br, I, —OH, —NO2, —NH2, —CN, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy-C1-6-alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkylamino-C1-6-alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl-C16-alkyl, C3-8 cycloalkyl-C2-6-alkenyl, C3-8 cycloalkyl-C2-6-alkynyl, C3-8 cycloalkyloxy-C2-6-alkynyl, C2-10 heterocyclyl, C2-10 heterocyclyl-C1-6-alkyl, C2-10 heterocyclyl-C2-6-alkenyl, C2-10 heterocyclyl-C2-6-alkynyl, C5-12 fused bicyclyl, C5-12 fused bicyclyl-C1-6-alkyl, C5-12 fused bicyclyl-C2-6-alkenyl, C5-12 fused bicyclyl-C2-6-alkynyl, C5-12 fused heterobicyclyl, C5-12 fused heterobicyclyl-C1-6-alkyl, C5-12 fused heterobicyclyl-C2-6-alkenyl, C5-12 fused heterobicyclyl-C2-6-alkynyl, C5-12 spiro bicyclyl, C5-12 spiro bicyclyl-C1-6-alkyl, C5-12 spiro bicyclyl-C2-6-alkenyl, C5-12 spiro bicyclyl-C2-6-alkynyl, C5-12 spiro heterobicyclyl, C5-12 spiro heterobicyclyl-C1-6-alkyl, C5-12 spiro heterobicyclyl-C2-6-alkenyl, C5-12 spiro heterobicyclyl-C2-6-alkynyl, C6-10 aryl, C6-10 aryl-C1-6-alkyl, C1-9 heteroaryl or C1-9 heteroaryl-C1-6-alkyl; R2 is H, F, Cl, Br, I, —NH2, —NO2, —CN or C1-6 alkyl; each of R3 and R4 is independently H, D or C1-4 alkyl; R5 is H; Ar is wherein each R6 is independently H, D, F, Cl, Br, I, C2-6 alkynyl, C6-10 aryl-C1-6-alkoxy, or C1-9 heteroaryl-C1-6-alkoxy; k is 0, 1, 2, 3, 4 or 5; and Ry is H or C6-10 aryl-C1-6-alkyl, wherein optionally each of alkyl, alkoxy, alkoxyalkyl, alkylamino, alkylaminoalkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkynyl, cycloalkyloxyalkynyl, heterocyclyl, heterocyclylalkyl, heterocyclylalkenyl, heterocyclylalkynyl, fused bicyclyl, fused bicyclylalkyl, fused bicyclylalkenyl, fused bicyclylalkynyl, fused heterobicyclyl, fused heterobicyclylalkyl, fused heterobicyclylalkenyl, fused heterobicyclylalkynyl, spiro bicyclyl, spiro bicyclylalkyl, spiro bicyclylalkenyl, spiro bicyclylalkynyl, spiro heterobicyclyl, spiro heterobicyclylalkyl, spiro heterobicyclylalkenyl, spiro heterobicyclylalkynyl, aryl, aryloxy, arylalkyl, arylalkoxy, arylamino, heteroaryl, heteroarylalkyl, heteroarylalkoxy, heteroaryloxy, alkylthio, alkylcarbonyl, alkylacylamino, alkylsulfonyl, haloalkyl and alkylsulfinyl is independently substituted with one or more substituents independently selected from D, F, Cl, Br, I, —OH, —NO2, —NH2, —CN, —COOH, C1-3 alkyl, C1-3 alkoxy, C1-3 alkylamino, C1-3 alkylthio, C6-10 aryl, C6-10 aryloxy, C6-10 arylamino, C1-9 heteroaryl, C1-9 heteroaryloxy, C3-8 cycloalkyl, C3-8 cycloalkyloxy, C2-10 heterocyclyl and C5-12 fused heterobicyclyl, and wherein optionally each of C1-3 alkyl, C1-3 alkoxy, C1-3 alkylamino, C1-3 alkylthio, C6-10 aryl, C6-10 aryloxy, C6-10 arylamino, C1-9 heteroaryl, C1-9 heteroaryloxy, C3-8 cycloalkyl, C3-8 cycloalkyloxy, C2-10 heterocyclyl and C5-12 fused heterobicyclyl is independently substituted with one or more substituents independently selected from D, F, Cl, Br, I, —OH, —NO2, —NH2, —CN, —COOH, C1-3 alkyl, deuterated C1-3 alkyl, C1-3 haloalkyl and hydroxy-substituted C1-3 alkyl. |
