Substituted-1<i>H</i>-benzo[<i>d</i>]imidazole series compounds as lysine-specific demethylase 1 (LSD1) inhibitors

摘要

The present invention provides compounds which are useful as inhibitors of lysine-specific demethylase 1 (“LSD1”). The present invention also relates to pharmaceutical compositions containing these compounds. The present invention also relates to a method for preparing these compounds. The present invention also relates to a method of treating a mammalian disorder in which LSD1 levels are elevated by administering these compounds and compositions to a patient in need thereof. The present invention also relates to a method for decreasing histone demethylase activity in a mammal comprising administering to the mammal an effective amount of these compounds and compositions.

主权项

1. A compound selected from the group consisting of:or a pharmaceutically acceptable salt, hydrochloric acid, sulphate, methanesulfonic acid or benzene sulfonic acid thereof.