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1. A compound which is selected from the compounds of formula (I): in which R1 and R2 independently of one another represent hydrogen, aminocarbonyl or (C1-C4)-alkyl, or R1 and R2 together with the carbon atom to which they are bonded form a (C3-C8)-cycloalkyl, R3 represents —(CH2)m—(SO2)OH or —O—(CH2)o—(SO2)OH,
wherein m and o independently of one another represent an integer 0, 1, 2 or 3, andwherein any CH2-group contained in the residues which R3 represents may be substituted with one or two (C1-C4)-alkyl-residues, X represents CR4 or N, R4 represents hydrogen or halogen, Z represents a bond or an alkyl-chain having one, two, three or four carbon atoms,
whereby the alkyl-chain may be substituted with one, two, three or four substituents, selected independently of one another from the group consisting of carboxy, aminocarbonyl and (C1-C4)-alkyl,
whereby alkyl in turn may be substituted with a substituent selected from the group consisting of hydroxy, carboxy and aminocarbonyl, Y represents a bond, O, NH or S, A represents (C6-C10)-aryl or 5- to 10-membered heteroaryl,
whereby aryl and heteroaryl are substituted with a substituent of the following formula wherein
R1b, R2b and R3b independently of one another represent hydrogen, amino, hydroxy, (C1-C4)-alkyl, (C1-C4)-alkoxy, (C3-C6)-cycloalkyl, 4-, 5-6- or 7-membered heterocyclyl or 5- or 6-membered heteroaryl,
whereby amino and hydroxy may be substituted with one or two substituents selected independently of one another from the group consisting of carbonyl, (C1-C4)-alkylcarbonyl, mono- or di-(C1-C4)-alkylaminocarbonyl, and (C1-C4)-alkyl,whereby alkoxy, heterocyclyl and heteroaryl may be substituted with one, two or three substituents selected independently of one another from the group consisting of halogen, hydroxy, amino, carbonyl, carboxy, (C1-C4)-alkylcarbonyl, (C1-C4)-alkoxy, mono- or di-(C1-C4)-alkylamino, mono- or di-(C1-C4)-alkylaminocarbonyl, —NH—CH(═NH), —NH—C(═NH)(NH2), —C(═NH)CH3 and (C1-C4)-alkyl, andwhereby alkyl and cycloalkyl may be substituted with one, two or three substituents selected independently of one another from the group consisting of halogen, hydroxy, amino, carbonyl, carboxy, carbonyloxy, aminocarbonyl, carbonylamino, (C1-C4)-alkylcarbonyl, (C1-C4)-alkoxy, mono- or di-(C1-C4)-alkylamino, mono- or di-(C1-C4)-alkylaminocarbonyl, —NH—CH(═NH), —NH—C(═NH)(NH2), —CH(═NH)CH3, (C6-C10)-aryl, 5- or 6-membered heteroaryl and 5- or 6-membered heterocyclyl, whereby heteroaryl and heterocyclyl in turn may be substituted with (C1-C4)-alkyl, and whereby amino in turn may be substituted with 5- or 6-membered heteroaryl, orR2b and R3b together with the nitrogen atom to which they are bonded form a 5- to 7-membered heterocycle including one, two or three further heteroatoms selected from the series N, O and S and R1b is as defined above,R4b represents hydrogen, amino, hydroxy, (C1-C4)-alkyl or (C1-C4)-alkoxy,
whereby amino and hydroxy may be substituted with one or two substituents selected independently of one another from the group consisting of (C1-C4)-alkylcarbonyl, mono- or di-(C1-C4)-alkylaminocarbonyl and (C1-C4)-alkyl,whereby alkoxy may be substituted with one, two or three substituents selected independently of one another from the group consisting of halogen, hydroxy, amino, carbonyl, carboxy, (C1-C4)-alkylcarbonyl, (C1-C4)-alkoxy, mono- or di-(C1-C4)-alkylamino, mono- or di-(C1-C4)-alkylaminocarbonyl, —NH—CH(═NH), —NH—C(═NH)(NH2), —CH(═NH)CH3 and (C1-C4)-alkyl, andwhereby alkyl may be substituted with one, two or three substituents selected independently of one another from the group consisting of halogen, hydroxy, amino, carbonyl, carboxy, aminocarbonyl, (C1-C4)-alkylcarbonyl, (C1-C4)-alkoxy, mono- or di-(C1-C4)-alkylamino, mono- or di-(C1-C4)-alkylaminocarbonyl, —NH—CH(═NH), —NH—C(═NH)(NH2), —CH(═NH)CH3, (C1-C4)-alkyl, (C6-C10)-aryl and 5- or 6-membered heteroaryl,R5b represents hydrogen or (C1-C4)-alkyl,Q represents a bond, CH2 or NH,k represents an integer 1 or 2, and* is the linkage site to the residue represented by A, andwhereby aryl and heteroaryl further may be substituted with one or two substituents selected independently of one another from the group consisting of halogen, cyano, amino, hydroxy, (C1-C4)-alkyl, (C1-C4)-alkoxy, mono- or di-(C1-C4)-alkylamino, amino-(C1-C4)-alkyl, hydroxy-(C1-C4)-alkyl or carboxy,
whereby alkyl, alkoxy, alkylamino, aminoalkyl, hydroxyalkyl and carboxy in turn may be substituted with a substituent selected from the group consisting of halogen, (C1-C4)-alkyl and carbonyl, and l represents an integer 0, 1, 2 or 3, and the salts thereof, the hydrates thereof and the hydrates of the salts thereof. |
