Composition and method for delivery of hydrophobic active agents

摘要

Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.

主权项

1. A delivery composition for local administration of a hydrophobic active agent, the delivery composition comprising:
a cationic delivery agent comprising an agent selected from the group consisting of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), polyamidoamine dendrimers (PAMAM), polypropylenimine, and polyethyleneimine (PEI) homopolymer; the hydrophobic active agent, wherein the hydrophobic active agent interfaces with the cationic delivery agent; and a pharmaceutically acceptable aqueous carrier; the cationic delivery agent effective to improve adhesion of the hydrophobic active agent to surfaces; wherein the delivery composition is in the form of a liquid immediately prior to local administration.