Monoclonal antibodies against HER2 epitope and methods of use thereof

摘要

This invention provides fully human monoclonal antibodies that recognize HER2. The invention further provides methods of using such monoclonal antibodies in a variety of therapeutic, diagnostic, and prophylactic indications.

主权项

1. A method of alleviating a symptom of a cancer in a subject in need thereof, the method comprising administering a conjugate to the subject in an amount sufficient to alleviate the symptom of the cancer, wherein the conjugate comprises an isolated antibody or antigen binding fragment thereof that specifically binds to an epitope of the human HER2 receptor and one or more therapeutic or diagnostic agents (D), wherein each D is independently connected directly or indirectly to the antibody or antigen binding fragment thereof, and wherein the antibody or antigen binding fragment thereof comprises a CDRH1 comprising the amino acid sequence FTFSSYSMN (SEQ ID NO: 25); a CDRH2 comprising the amino acid sequence YISSSSSTIYYADSVKG (SEQ ID NO: 26); a CDRH3 comprising the amino acid sequence GGHGYFDL (SEQ ID NO: 27); a CDRL1 comprising the amino acid sequence RASQSVSSSYLA (SEQ ID NO: 28); a CDRL2 comprising the amino acid sequence GASSRAT (SEQ ID NO: 21); and a CDRL3 comprising the amino acid sequence QQYHHSPLT (SEQ ID NO: 29).