| 主权项 |
1. A compound according to Formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from NRaRa, C1-4alkyl optionally substituted with OH, CN, and aryl, C2-4alkenyl optionally substituted with OH, CN, and C6-15 aryl, —(CRdRd)r—C3-13 carbocyclyl substituted with 0-5 R11, and —(CRdRd)r-4- to 14-membered heterocyclyl comprising carbon atoms and 1 to 3 heteroatoms selected from N, NR12, O, S, and substituted with 0-5 R11; R2 is selected from H, C1-4alkyl, F, Cl, Br, and CN; R3 is selected from H and C1-4alkyl; R4 is selected from H, C1-4alkyl, F, Cl, Br, and CN; R5 is selected from H, C1-4alkyl substituted with 0-4 Re, —(CH2)r—C3-6 carbocyclyl substituted with 0-4 Re, and —(CH2)r-4- to 14-membered heterocyclyl comprising carbon atoms and 1 to 3 heteroatoms selected from N, NR8, O, S, and substituted with 0-4 Re; R6, is selected from H, C1-6alkyl substituted with 0-3 Re, and C3-6carbocyclyl substituted with 0-3 Re; or R5 and R6 together with the nitrogen atom and the adjacent carbon atom to which they are respectively attached form a 4- to 14-membered heterocyclic ring substituted with 0-5 R9; R7 is aryl substituted with 0-3 Re; R8 is selected from H, C1-4 alkyl substituted with 0-3 Re, —(CH2)rORb, (CH2)rS(O)pRc, —(CH2)rC(═O)Rb, —(CH2)rNRaRa, —(CH2)rC(═O)NRaRa, —(CH2)rC(═O)(CH2)rNRaRa, —(CH2)rNRaC(═O)Rb, —(CH2)rNRaC(═O)ORb, —(CH2)rOC(═O)NRaRa, —(CH2)rNRaC(═O)NRaRa, —(CH2)rC(═O)ORb, —(CH2)rS(O)2NRaRa, —(CH2)rNRaS(O)2NRaRa, —(CH2)rNRaS(O)2Rc, (CH2)r—C3-6 carbocyclyl substituted with 0-3 Re, and —(CH2)r-4- to 14-membered heterocyclyl comprising carbon atoms and 1 to 4 heteroatoms selected from N, O, S and substituted with 0-3 Re; R9 is selected from C1-4 alkyl substituted with 0-3 Re, —(CH2)rNRaRa, —(CH2)rC(═O)Rb, —(CH2)rC(═O)ORb, —(CH2)rC(═O)NRaRa, S(O)pRc, (CH2)r—C3-6 carbocyclyl substituted with 0-3 Re, and —(CH2)r-4- to 14-membered heterocyclyl comprising carbon atoms and 1 to 4 heteroatoms selected from N, O, S and substituted with 0-3 Re; R11, at each occurrence, is independently selected from H, F, Cl, Br, ═O, CN, NO2, —ORb, —S(O)pRc, —C(═O)Rb, —(CRdRd)rNRaRa, —(CRdRd)rC(═O)NRaRa, —NRaC(═O)Rb, —NRaC(═O)ORb, —OC(═O)NRaRa, —NRaC(═O)NRaRa, —(CRdRd)rC(═O)ORb, —S(O)2NRaRa, —NRaS(O)2NRaRa, —NRaS(O)2Rc, C1-6 alkyl substituted with 0-5 Re, —(CRdRd)r—C3-6carbocyclyl substituted with 0-5 Re, and —(CRdRd)r-4- to 14-membered heterocyclyl substituted with 0-5 Re; R12 is selected from H, —C(═O)Rb, C1-6 alkyl substituted with 0-5 Re, —(CH2)r—C3-6carbocyclyl substituted with 0-5 Re, and —(CH2)r-4- to 14-membered heterocyclyl comprising carbon atoms and 1 to 4 heteroatoms selected from N, O, S and substituted with 0-5 Re; Ra, at each occurrence, is independently selected from H, CN, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, —(CH2)r—C3-10carbocyclyl substituted with 0-5 Re, and —(CH2)r-4- to 14-membered heterocyclyl comprising carbon atoms and 1 to 4 heteroatoms selected from N, O, S and substituted with 0-5 Re; or Ra and Ra together with the nitrogen atom to which they are both attached form a 4- to 14-membered heterocyclic ring comprising carbon atoms and 1 to 4 heteroatoms selected from N, O, S and substituted with 0-5 Re; Rb, at each occurrence, is independently selected from H, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, —(CH2)r—C3-10carbocyclyl substituted with 0-5 Re, and —(CH2)r-4- to 14-membered heterocyclyl comprising carbon atoms and 1 to 4 heteroatoms selected from N, O, S and substituted with 0-5 Re; Rc, at each occurrence, is independently selected from C1-6 alkyl substituted with 0-5 Re, C2-6alkenyl substituted with 0-5 Re, C2-6alkynyl substituted with 0-5 Re, C3-6carbocyclyl, and 4- to 14-membered heterocyclyl comprising carbon atoms and 1 to 4 heteroatoms selected from N, O, S; Rd, at each occurrence, is independently selected from H and C1-4alkyl substituted with 0-5 Re; Re, at each occurrence, is independently selected from C1-6 alkyl substituted with 0-5 Rf, C2-6 alkenyl, C2-6 alkynyl, —(CH2)r—C3-6 cycloalkyl, F, Cl, Br, CN, NO2, ═O, CO2H, —(CH2)rOC1-5 alkyl, —(CH2)rORf, S(O)pRf, S(O)pNRfRf, and —(CH2)rNRfRf; Rf, at each occurrence, is independently selected from H, C1-5 alkyl, C3-6 cycloalkyl, and phenyl, or Rf and Rf together with the nitrogen atom to which they are both attached form a heterocyclic ring optionally substituted with C1-4alkyl; p, at each occurrence, is independently selected from zero, 1, and 2; and r, at each occurrence, is independently selected from zero, 1, 2, 3, and 4. |
