发明名称 |
Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith |
摘要 |
Provided herein are diaminopyrimidyl Compounds having the following structures:;wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta. |
申请公布号 |
US9556126(B2) |
申请公布日期 |
2017.01.31 |
申请号 |
US201414576197 |
申请日期 |
2014.12.19 |
申请人 |
Signal Pharmaceuticals, LLC |
发明人 |
Papa Patrick;Cathers Brian Edwin;Calabrese Andrew Antony;Whitefield Brandon Wade;Bennett Brydon;Cashion Daniel;Mortensen Deborah;Huang Dehua;Torres Eduardo;Parnes Jason;Sapienza John;Hansen Joshua;Leftheris Katerina;Correa Matthew;Delgado Maria Mercedes;Raheja Raj K.;Bahmanyar Sogole;Hegde Sayee;Norris Stephen;Plantevin-Krenitsky Veronique |
分类号 |
C07D403/12;A61K31/505;C07D239/48;C07D401/12;C07D409/12;C07D413/12;C07D405/12;C07D471/04;C07D405/14;A61K31/506;C07D417/12 |
主分类号 |
C07D403/12 |
代理机构 |
Jones Day |
代理人 |
Jones Day |
主权项 |
1. A compound of formula (I): or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein: X is CN or CF3; L is (C1-4 alkyl); R1 is substituted or unsubstituted heteroaryl; and R2 is substituted or unsubstituted cycloalkyl. |
地址 |
San Diego CA US |