主权项 |
1. A compound of Formula II: wherein W is —C(O)—, —S(O)—, or —S(O)2—; R is an aryl or bicyclic heteroaryl; wherein said heteroaryl contains 1, 2, or 3 heteroatoms independently selected from N, S, and O, with the proviso that no two adjacent ring heteroatoms are both S or both O; and each of said aryl or heteroaryl is optionally substituted with one or more substituents which can be the same or different and are independently selected from the group consisting of deuterium, halo, cyano, amino, aminoalkyl, (amino)alkoxy, —CONH2, —C(O)NH(alkyl), —C(O)N(alkyl)2, —C(O)NH(aryl), —C(O)N(aryl)2, —CF3, —CHF2, —CH2F, -alkyl, alkoxy, hydroxyl, hydroxyalkyl, (alkoxyalkyl)amino, —N(R3)—C(O)-alkyl, —N(R3)—C(O)-aryl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, with the proviso that no two adjacent ring heteroatoms in said heteroaryl are both S or both O; G is aryl, heteroaryl, cycloalkyl, heterocycloalkyl or —NR1R2; wherein each of said aryl, heteroaryl, heterocycloalkyl, and cycloalkyl is either unsubstituted or substituted with 1, 2, 3, or 4 substituents which can be the same or different and are independently selected from the group consisting of deuterium, halo, cyano, amino, aminoalkyl, (amino)alkoxy-, —CONH2, —C(O)NH(alkyl), —C(O)N(alkyl)2, —C(O)NH(aryl), —C(O)N(aryl)2, —CF3, —CHF2, —CH2F, alkyl, alkenyl, alkynyl, alkoxy, hydroxyl, hydroxyalkyl, aryloxy, (alkoxyalkyl)amino, —N(R3)—C(O)-alkyl, —N(R3)—C(O)-aryl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; and R1 and R2 are the same or they are different, and are independently selected from H, C1 to C7 alkyl, C1 to C7 alkoxy, C1 to C4 hydroxyalkyl, aryl, heteroaryl, heterocycloalkyl, and cycloalkyl, and wherein heteroatoms of said heteroaryl and heterocycloalkyl are independently selected from N, O, and S, with the proviso that no two adjacent ring heteroatoms are both S or both O; and further wherein R1 and R2 are each unsubstituted or optionally substituted with one or more substituents which can be the same or different and are independently selected from the group consisting of deuterium, halo, cyano, amino, aminoalkyl, (amino)alkoxy, —CONH2, —C(O)NH(alkyl), —C(O)N(alkyl)2, —C(O)NH(aryl), —C(O)N(aryl)2, —CF3, —CHF2, —CH2F, alkyl, hydroxyalkyl, -alkoxy, hydroxyl, hydroxyalkyl, carboxy, (alkoxyalkyl)amino, -alkylamine, aminocarbonyl, —CHO, —N(R3)—C(O)-alkyl, —N(R3)—C(O)-aryl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; R3 is H, alkyl or arylalkyl; and n is 4, 5 or 6; or a pharmaceutically acceptable salt thereof. |