| 摘要 |
The present invention relates to co-assembled nanoparticles comprising at least one polypeptide comprising a polyanion; and at least one amphiphilic peptide capable of forming a β-sheet structure, a derivative or a salt thereof, the amphiphilic peptide comprising at least 2 pairs of alternating hydrophobic/hydrophilic amino acid residues, wherein the hydrophilic amino acid residue is positively charged, and methods of preparation of said nanoparticles. There are further provided pharmaceutical compositions comprising the co-assembled nanoparticles and a pharmaceutically active ingredient, dissolved, entrapped, encapsulated or attached to the co- assembled nanoparticles. The present invention further provides therapeutic uses of said pharmaceutical compositions. |
