Modification of peptides using a bis(thioether)arylbridge approach

摘要

This invention provides novel methods of stabilizing peptides and peptides so stabilized. In certain embodiments the methods involve providing a peptide containing at least two S bearing residues within the peptide; and reacting the peptide with a di-halogen-aryl-compounds to form a bis(thioether)-aryl-bridge between said two residues.

主权项

1. A peptide stabilized with at least one bis(thioether)aryl bridge between two S-bearing residues within said peptide, wherein the amino acid sequence of said peptide comprises the sequence of a peptide selected from the group consisting of ArB14Bo (SEQ ID NO:6), ArB14Co (SEQ ID NO:7), ArB14Co-AZT (SEQ ID NO:8), ArB14Co-CLB (SEQ ID NO:9), ArB14Co-Ch (SEQ ID NO:10), ArB14C-Ch/CLB (SEQ ID NO:11), ArB14Co-MTX (SEQ ID NO:12), and ArB14Co-TFA (SEQ ID NO:13).