Aliphatic amine polymer salts for tableting

摘要

The tablets, compositions and methods of the present invention, comprising a carbonate salt of an aliphatic amine polymer and s monovalent anion can prevent or ameliorate acidosis, in particular acidosis in patients with renal disease. The tablets and compositions of the present invention maintain a disintegration time of no greater than 30 minutes at 37° C. and at pH of at least 1 for a period of at least ten weeks at 60° C. Furthermore, the tablets are stable for extended periods of time without the need for specialized storage conditions.

主权项

1. A method of treating hyperphosphatemia in a patient in need thereof, comprising administering a tablet comprising a tablet core, wherein said tablet core comprises:
i) a therapeutically acceptable amount of sevelamer carbonate; and ii) sodium chloride, wherein the chloride of the sodium chloride is present in a range of between 0.1 to 1% by weight relative to the combined weights of the sevelamer carbonate and the sodium chloride.