Lyophilization of synthetic liposomal pulmonary surfactant

摘要

Lyophilized pulmonary surfactants having an increased specific surface area and porosity are described. Methods of making the lyophilized pulmonary surfactants are also described.

主权项

1. A lyophilized synthetic pulmonary surfactant composition comprising:
at least one phospholipid and a synthetic polypeptide having at least 10 amino acid residues and represented by a formula:
(ZaUb)cZd wherein Z represents a hydrophilic amino acid residue and U represents a hydrophobic amino acid residue; wherein each Z is independently R, D, E or K; and each U is independently V, I, L, C, Y, or F; and wherein a is an integer with an average value of about 1 to about 5; b is an integer with an average value of about 3 to about 20; c is an integer of about 1 to about 10; and d is an integer of about 1 to about 3, wherein the lyophilized synthetic pulmonary surfactant composition has a specific surface area at least 2.2 m2/g or a porosity above 40% by volume of a total area of the lyophilized synthetic pulmonary surfactant.