| 摘要 |
The present invention relates to a compound having the structural formula described below or a pharmaceutically acceptable salt thereof, wherein Ris H; Ris phenyl substituted with 0, 1, 2 or 3 substituents independently selected from -(C-Calkyl), -(C-Chaloalkyl), -NHC(O)(C-Calkyl), NRR, -O-(C-Calkyl), -O-(C-Cfluoroalkyl), -C(O)(C-Calkyl), -S(O)(C-Calkyl), -halogen, -CN; Yis N or CH; T iswherein Q is a single bond, -CH-, -O-, -CH(CH)-, -C(O)- or -S(O)-; the ring system denoted by "A" is phenyl; each Ris independently selected from -(C-Calkyl), -(C-Chaloalkyl), -NHC(O)(C-Calkyl), C(O)NRR, -NRR, -O(C-Calkyl), -O(C-Cfluoroalkyl), C(O)(C-Calkyl), -C(O)(C-Cfluoroalkyl), -S(O)(C-Calkyl), -S(O)(C-Cfluoroalkyl), -halogen, -N, -SF, -NOand -CN; and y is 0, 1, 2 or 3; wherein each Rand Ris independently selected from H and -(C-Calkyl), and each Ris independently selected from -H and - (C-Calkyl). The invention also relates to pharmaceutical compositions comprising said compounds. The a compound activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions. |
