| 摘要 |
The invention relates to Corey-type aldehydic haloesteric and γ-lactonic intermediates, with the aldehydic group protected as cyclic acetals or thioacetals, used for the synthesis of prostaglandin analogues. The haloesteric, racemic or (+)- or (-)- enantiomeric pure intermediates, correspond to the formula 1, where Hlg is a Cl, F, Br or I atom, X is O or S, n is 0...3, R is a protective etheric, silyl-etheric, trityl group or an esteric group. The γ-lactonic racemic or (+)- or (-)- enantiomeric pure intermediates correspond to the formula 2 where X, R and n are the same as above. |
