| 摘要 |
The invention relates to a method for producing microparticles or nanoparticles of water-soluble and water-insoluble substances by controlled precipitation, co-precipitation and self-organization processes in microjet reactors, wherein a solvent, which contains at least one target molecule, and a nonsolvent are mixed as jets that collide with each other in a microjet reactor at defined pressures and flow rates, wherein very rapid precipitation, co-precipitation or a chemical reaction occurs, during the course of which microparticles or nanoparticles are formed. In order to create such a method, with which the particle size of the resulting microparticles or nanoparticles can be specifically controlled, it is proposed within the scope of the invention that particle size be controlled by the flow rate of the solvent and the nonsolvent and/or the amount of gas, wherein smaller particles sizes are obtained at the higher flow rate of the solvent and the non-solvent, or in the complete absence of gas. The particle size can be further controlled by the temperature at which the collision of the solvent with the non-solvent occurs, wherein smaller particles sizes are obtained at lower temperatures. |
