发明名称 |
A delayed release drug formulation |
摘要 |
Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and the coating comprises an inner layer and an outer layer. The outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria, and a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a third polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said third polymeric material being selected from an at least partially neutralised polycarboxylic acid and a non-ionic polymer. In embodiments in which the third polymeric material is a non-ionic polymer, the inner layer comprises at least one of a buffer agent and a base. Advantages of formulations according to the present invention include accelerated release of the drug when exposed to colonic conditions and reduction or elimination of a food and/or alcohol effect on drug release after administration. |
申请公布号 |
NZ629260(A) |
申请公布日期 |
2017.01.27 |
申请号 |
NZ20130629260 |
申请日期 |
2013.04.29 |
申请人 |
TILLOTTS PHARMA AG |
发明人 |
Basit Abdul Waseh;Bravo González Roberto Carlos;Buser Thomas;Goutte Frédéric Jean-Claude;Varum Felipe Jose Oliveria;Freire Ana Cristina |
分类号 |
A61K9/00;A61K9/28;A61K31/196;A61K31/606;A61K31/616;A61K47/32;A61K47/36;A61K47/38 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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