Prodrugs of fumarates and their use in treating various diseases

摘要

Disclosed are prodrugs of fumaric acid esters or fumarates of formula (III) where the variables are as disclosed in the specification. The compounds are useful in the treatment of neurological diseases such as multiple sclerosis. Examples of compounds include: 2-(4,4-Dimethyl-2,5-dioxoimidazolidin-1-yl)ethyl methyl fumarate; 3-(2,5-Dioxopyrrolidin-1-yl)propyl methyl fumarate and 2-(1,3-Dioxoisoindolin-2-yl)ethyl methyl fumarate.