| 主权项 |
1. A process for preparing oxymorphone or a salt or solvate thereof from a 14-hydroxymorphinone salt or a solvate thereof the process comprising the steps of (a) providing a solution or suspension of the 14-hydroxymorphinone salt or a solvate thereof; (b) adding trifluoroacetic acid and/or a glycol; and (c) hydrogenating the resulting mixture, thus reducing to reduce the 14-hydroxymorphinone to the oxymorphone, wherein Xn− is an anion selected from the group consisting of Cl−, HSO4−, SO42−, methanesulfonate, tosylate, trifluoroacetate, H2PO4−, HPO42−, PO43−, oxalate, perchlorate, and any mixtures thereof; and n is 1,2, or 3. |
