| 主权项 |
1. A compound of Formula I:or a pharmaceutically acceptable salt thereof, wherein:
W is selected from hydrogen andwherein Ring A is selected from monocyclic or bicyclic aryl, monocyclic or bicyclic heteroaryl, cycloalkyl and heterocyclyl;
Z is selected from C1-C6 alkyl, cycloalkyl, monocyclic or bicyclic aryl, monocyclic or bicyclic aralkyl, monocyclic or bicyclic heteroaryl, monocyclic or bicyclic heterocyclyl, and monocyclic or bicyclic heterocyclylalkyl; wherein each of C1-C6 alkyl, cycloalkyl, monocyclic or bicyclic aryl, monocyclic or bicyclic aralkyl, monocyclic or bicyclic heteroaryl, monocyclic or bicyclic heterocyclyl, monocyclic and bicyclic heterocyclylalkyl is independently substituted with 0-5 occurrences of RC; L is selected from —N(R1)—C(O)—, —N(R1)C(O)N(R1)—, —N(R1)C(O)N(R1)—(C1-C6 alkylene)-, N(R1)—(C1-C6 alkylene)-, —N(R1)—C(O)—(C1-C6 alkylene)-, —N(R1)—S(O)2, and —N(R1)—S(O)2—(C1-C6 alkylene)-; wherein each alkylene is independently substituted with 0-5 occurrences of R2; each RA is independently selected from C1-C6 alkyl, C1-C6 alkoxy, halo, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 heteroalkyl, —N(R1)(R1), cyano, and —OR1; each RB is independently selected from hydrogen, C1-C6 alkyl, C1-C6 cycloalkyl, hydroxyl, halo, C1-C6 alkoxy, C1-C6 haloalkyl, —N(R1)(R1), and cyano; each RC is independently selected from C1-C6 alkyl, C1-C6 alkynyl, halo, C1-C6 heteroalkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 hydroxyalkyl, cycloalkyl, monocyclic or bicyclic aryl, monocyclic or bicyclic aryloxy, monocyclic or bicyclic aralkyl, monocyclic or bicyclic heterocyclyl, monocyclic or bicyclic heterocyclylalkyl, nitro, cyano, —C(O)R1, —OC(O)R1, —C(O)OR1, —SR1, —S(O)2R1, —S(O)2—N(R1)(R1), —(C1-C6 alkylene)-S(O)2—N(R1)(R1), —N(R1)(R1), —C(O)—N(R1)(R1), —N(R1)(R1)—C(O)R1, —(C1-C6 alkylene)-N(R1)—C(O)R1, —NR1S(O)2R1, —P(O)(R1)(R1), and —OR1; wherein each of heteroalkyl, haloalkyl, haloalkoxy, alkyl, alkynyl, cycloalkyl, aryl, aryloxy, aralkyl, heterocyclyl, heterocyclylalkyl is independently substituted with 0-5 occurrences of Ra; or 2 RC together with the carbon atom(s) to which they are attached form a cycloalkyl or heterocyclyl ring substituted with 0-5 occurrences of Ra; each RD is independently selected from halo, C1-C6 alkyl, C1-C6 cycloalkyl, hydroxyl, halo, C1-C6 alkoxy, C1-C6 haloalkyl, —N(R2)(R2), and cyano; each R1 is independently selected from hydrogen, hydroxyl, halo, thiol, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 thioalkyl, —NR″R″, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl, wherein each of C1-C6 alkyl, cycloalkyl and heterocyclyl is independently substituted with 0-5 occurrences of Rb; or 2 R1 together with the atom(s) to which they are attached form a cycloalkyl or heterocyclyl ring; each R2 is independently selected from hydroxyl, C1-C6 alkyl, C1-C6 alkoxyl, —NR′R′; or 2 R2 together with the atom(s) to which they are attached form a cycloalkyl or heterocyclyl ring; each Ra and Rb is independently selected from hydrogen, halo, cyano, hydroxyl, C1-C6 alkoxyl, —C(O)R″, C(O)OR′, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 heteroalkyl, C1-C6 hydroxyalkyl, —NR′R′, and cycloalkyl, wherein cycloalkyl is substituted with 0-5 occurrences of R′; each R′ is independently selected from hydrogen, C1-C6 alkyl, C1-C6 alkoxyl, C1-C6 heteroalkyl, halo, hydroxyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, cycloalkyl and cyano; or 2R′ together with the atom(s) to which they are attached form a cycloalkyl or heterocyclyl ring; each R″ is hydrogen, C1-C6 alkyl, —C(O)—C1-C6 alkyl, —C(O)—NR′R′; or —C(S)—NR′R′; and each q and r is independently 0, 1, 2, 3, or 4. |
