| 发明名称 |
SYSTEMS AND METHODS FOR TREATMENTS OF AN EYE WITH A PHOTOSENSITIZER |
| 摘要 |
A formulation for an eye treatment includes a photosensitizer and a permeability enhancing composition. The permeability enhancing composition includes one or more permeability enhancers. The permeability enhancing composition has a hydrophilic and lipophilic balance increases a permeability of an area of the eye for the photosensitizer. The hydrophilic and lipophilic balance can be characterized by a Hydrophile-Lipophile Balance (HLB) number. For example, the area of the eye may include a corneal epithelium, the photosensitizer may include riboflavin, and the permeability enhancing composition may have a corresponding HLB number between approximately 12.6 and approximately 14.6. |
| 申请公布号 |
US2017021021(A1) |
申请公布日期 |
2017.01.26 |
| 申请号 |
US201615216344 |
申请日期 |
2016.07.21 |
| 申请人 |
Avedro, Inc. |
发明人 |
Kamaev Pavel;Friedman Marc D. |
| 分类号 |
A61K41/00;A61K33/00;A61N5/06;A61K31/525;A61F9/00;A61K9/00;A61K47/02 |
主分类号 |
A61K41/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A formulation for an eye treatment, comprising:
a photosensitizer; and a permeability enhancing composition including one or more permeability enhancers, the permeability enhancing composition having a Hydrophile-Lipophile Balance (HLB) number indicating that the permeability enhancing composition increases a permeability of an area of the eye for the photosensitizer. |
| 地址 |
Waltham MA US |
