GENETIC POLYMORPHISMS ASSOCIATED WITH PSORIASIS, METHODS OF DETECTION AND USES THEREOF

摘要

The present invention is based on the discovery of genetic polymorphisms that are associated with psoriasis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, such as a haplotype, a diplotype, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

主权项

1. A method for identifying an individual who has an altered risk for developing psoriasis, comprising detecting at least one single nucleotide polymorphism (SNP) in any one of the nucleotide sequences of SEQ ID NOS:7-12 and 24-89 in said individual's nucleic acids, wherein the presence of the SNP is indicative of an altered risk for psoriasis in said individual.