POLYSACCHARIDE AND PROTEIN-POLYSACCHARIDE CROSS-LINKED HYDROGELS FOR SOFT TISSUE AUGMENTATION

摘要

Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and optionally including proteins. In one aspect, hyaluronic acid-based compositions described herein include zero-length cross-linked moieties and optionally at least one active agent. The present hyaluronic acid-based compositions have enhanced flow characteristics, hardness, and persistence compared to known hyaluronic acid-based compositions. Methods and processes of preparing such hyaluronic acid-based compositions are also provided.

主权项

1. An injectable dermal filler, comprising:
a hydrogel comprising a hyaluronic acid polymer crosslinked with collagen via a zero-length crosslinking agent; wherein said hydrogel is prepared by:
(a) reacting said hyaluronic acid polymer with said collagen via said zero-length cross-linking agent, thereby providing a crosslinked hyaluronic acid/collagen-based composition; and(b) sterilizing the crosslinked hyaluronic acid/collagen-based composition via irradiation with ultraviolet light, visible light, microwaves or a combination thereof.