COMBINATION THERAPY WITH CD4 LYMPHOCYTE DEPLETION AND MTOR INHIBITORS

摘要

The invention provides methods for treating a malignant neoplastic cell proliferative disorder or disease, comprising administering to a subject in need thereof an effective amount of an mTOR inhibitor and an effective amount of a CD4 lymphocyte depleting agent. Such methods find utility in the treatment of certain subsets of malignant neoplastic cell proliferative disorders or diseases, e.g. renal cell carcinoma and melanoma. The invention also provides for pharmaceutical compositions comprising a therapeutically effective amount of an mTOR inhibitor and an effective amount of a CD4 lymphocyte depleting agent in a pharmaceutically acceptable carrier.

主权项

1. A method of treating malignant neoplastic cell proliferative disorders or diseases in a subject in need thereof, comprising:
(i) providing a composition comprising an mTOR inhibitor and a CD4 lymphocyte depleting agent, and (ii) administering a therapeutically effective amount of the composition to the subject to treat a malignant neoplastic cell proliferative disorder or disease, thereby treating malignant neoplastic cell proliferative disorders or diseases.