AUGMENTATION OF CANCER AND CANCER ENDOTHELIAL VACCINE IMMUNOGENICITY BY HISTONE DEACETYLASE INHIBITORS

摘要

Disclosed are protocols, procedures and therapeutic compositions useful for augmentation of immunity to cancer and cancer associated endothelial cells by treatment with histone deacetylase (HDAC) inhibitors capable of augmenting stimulatory and costimulatory molecules on said cancer vaccines. Additionally, the invention teaches specific concentrations of HDAC inhibitors useful for stimulation of in vivo immunity to tumor and tumor endothelial cell targeting vaccines.

主权项

1. A composition useful for induction of immune response to tumor associated endothelium produced by:
a) obtaining a population of endothelial cells; b) inducing said endothelial cells to proliferate; and c) treating said endothelial cells with a histone deacetylase inhibitor for a sufficient time and concentration to induce sensitivity of said proliferating endothelial cells to natural killer cell mediated killing.