METHODS OF MODELLING INTERACTIONS BETWEEN BIOMARKERS

摘要

The present invention provides a method of modelling the interaction between different biomarkers or other patient measurements and their progression along the trajectory of a neurodegenerative disease, the method comprising the steps of:a) obtaining longitudinal biomarker profiles from multiple subjects by measuring one or more predetermined biomarkers over time;b) storing said longitudinal biomarker profiles in a first memory; c) using a computer system to perform temporal alignment of said longitudinal biomarker profiles;d) defining a parametric model for eachof said one or more biomarkers;e) fitting an appropriate parametric model to each longitudinal biomarker profile for each subject;g) defining a biomarker signature for each longitudinal biomarker profile;and h) forming a global disease model by combining individual parametric models and biomarker signatures.