| 主权项 |
1. A compound represented by Formula (I):
X-A1-Y-A2-Z-L-R (I),or a pharmaceutically acceptable salt thereof, wherein:
X is an optionally substituted aryl or optionally substituted heteroaryl; A1 is absent, or selected from the group consisting of —NH—, —NHC(O)—, —NHC(O)N(R3)—, and optionally substituted azolyl; Y is an optionally substituted aryl or optionally substituted heteroaryl; A2 is absent or —N(R4)—; Z is —CRaRb—; wherein Ra and Rb are each independently selected from the group consisting of hydrogen, OH, OMe, halogen, and methyl optionally substituted with 1 to 3 substituents selected from the group consisting of fluoro, chloro, OH, and OMe; wherein at least one of Ra and Rb is not hydrogen; alternatively, Ra, Rb, and the carbon atom to which they are attached form an oxetanyl, 5- to 6-membered cyclic ketal, or —C(═CF2)—; L is —NR1—, O or —CR1R2—; and R, R1, R2, R3 and R4 at each occurrence are independently selected from the group consisting of hydrogen, optionally substituted —C1-C8 alkyl, optionally substituted —C2-C8 alkenyl, optionally substituted —C2-C8 alkynyl, optionally substituted —C3-C8 cycloalkyl, optionally substituted 3- to 8-membered heterocyclic, optionally substituted aryl and optionally substituted heteroaryl; alternatively, R1 and R2 or R1 and R are taken together with the atom to which they are attached to form an optionally substituted C3-C8 cycloalkyl or an optionally substituted 3- to 8-membered heterocyclic. |
