发明名称 |
HIGH THROUGHPUT SCREENING ASSAY FOR IDENTIFYING INHIBITORS OF RAD52 AND USES OF THE IDENTIFIED INHIBITORS FOR TREATMENT AND/OR PREVENTION OF MALIGNACIES |
摘要 |
Disclosed are methods, compositions, kits, and systems for identifying small- molecule drugs for treating cancer in a subject. The disclosed methods, compositions, kits, and systems may be utilized to identify small-molecule inhibitors of radiation sensitive protein 52 (RAD52) in order to treat cancer in a subject, such as breast cancer in a subject having a BRCA1- deficient, BRCA2 -deficient, and/or PALB2 -deficient phenotype by administering the identified small-molecule inhibitors to the subject. |
申请公布号 |
WO2017015187(A1) |
申请公布日期 |
2017.01.26 |
申请号 |
WO2016US42730 |
申请日期 |
2016.07.18 |
申请人 |
UNIVERSITY OF IOWA RESEARCH FOUNDATION |
发明人 |
SPIES, Michael, Ashley;SPIES, Maria;HENGEL, Sarah, R. |
分类号 |
A61K31/06;A61K31/235;A61K31/353;A61K31/4709;A61K31/7048;G01N33/574 |
主分类号 |
A61K31/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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