| 发明名称 |
SELECTIVE INHIBITORS OF Alpha2-CONTAINING ISOFORMS OF Na,K-ATPase AND USE THEREOF FOR REDUCTION OF INTRAOCULAR PRESSURE |
| 摘要 |
Provided herein are alpha2- selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions. |
| 申请公布号 |
WO2017013648(A1) |
申请公布日期 |
2017.01.26 |
| 申请号 |
WO2016IL50785 |
申请日期 |
2016.07.19 |
| 申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD. |
发明人 |
KARLISH, Steven J.D.;KATZ, Adriana;TAL, Daniel M.;MARCOVICH, Arie |
| 分类号 |
C07J19/00;A61K31/7052;A61P9/00;A61P27/06;C07H17/00 |
主分类号 |
C07J19/00 |
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