摘要 |
The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion. |
申请人 |
ABBVIE INC. |
发明人 |
ASMUS, Katharin;GAO, Yi;GARRETT, Colleen;HACH, Harald;JAYASANKAR, Adivaraha;KYEREMATENG, Samuel;LANDER, Ute;MUELLER, Thomas;NARIS, Marius;OBERMILLER, Constanze;REUL, Regina;SCHNEIDER, Katrin;SEVER, Nancy;SIIMON, Michael;STEITZ, Benedikt;TONG, Ping;WESTEDT, Ulrich;ZHU, Donghua |