发明名称 |
PROCESS FOR INDUCING RESISTANCE TO DIPHTHERIA TOXIN IN HUMAN CELLS, PRODUCTS AND USES THEREOF |
摘要 |
Process for inducing resistance to diphtheria toxin in a human cell, wherein the process is carried out in vitro and/or in vivo in a rodent xenografted with a human cell, the process comprising: a) providing at least one expression vector containing at least one nucleotide sequence targeting by RNA interference the DPH2 gene transcript of the human cell; c) transducing the at least one vector into the human cell; d) allowing transcription in the human cell, from the at least one expression vector, of the at least one nucleotide sequence targeting by RNA interference the DPH2 gene transcript; e) obtaining silencing of the DPH2 gene in the human cell, whereby the human cell is resistant to diphtheria toxin. |
申请公布号 |
WO2017013585(A1) |
申请公布日期 |
2017.01.26 |
申请号 |
WO2016IB54293 |
申请日期 |
2016.07.19 |
申请人 |
UNIVERSITÀ DEGLI STUDI DI TORINO |
发明人 |
MEDICO, Enzo;PICCO, Gabriele |
分类号 |
C12N15/113;C12N5/10 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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