| 发明名称 |
HUMAN EPITHELIAL CELL LINE FOR 3-D MODELIZING OF CANCER AND TREATMENT THEREOF |
| 摘要 |
A cellular model is described that targets dysregulation or inappropriate activation of the Sonic Hedgehog/Patched (SHH/PTCH) pathway. Also described, is a screening method using this cellular model to screen for pharmacological compounds that can treat or prevent skin cancer, in particular, Basal Cell Carcinoma (BCC) lesions. |
| 申请公布号 |
US2017023549(A1) |
申请公布日期 |
2017.01.26 |
| 申请号 |
US201615053603 |
申请日期 |
2016.02.25 |
| 申请人 |
GALDERMA RESEARCH & DEVELOPMENT ;CNRS |
发明人 |
BURTY Elodie;MAGNALDO Thierry;GACHE Yannick;AUBERT Jérôme |
| 分类号 |
G01N33/50;C12N5/071 |
主分类号 |
G01N33/50 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An immortalized cell line of human nevoid basal cell carcinoma syndrome keratinocytes (KNBCCS6 E6/E7), wherein the cell line has a heterozygous mutation in the PATCHED1 (PTCH 1) gene; and the cell line has stable expression overtime, even after a high rate from passages in tissue culture. |
| 地址 |
Biot FR |
