GENETIC POLYMORPHISMS ASSOCIATED WITH CORONARY EVENTS AND DRUG RESPONSE, METHODS OF DETECTION AND USES THEREOF

摘要

The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.

主权项

1. A method for identifying a human who has an altered risk for developing CHD or aneurysm/dissection, comprising detecting a SNP in any one of the nucleotide sequences of SEQ ID NOS:1 and 3-132 or a complement thereof, in said human's nucleic acids, wherein the presence of the SNP is indicative of an altered risk for CHD or aneurysm/dissection in said human.