发明名称 PEPTIDES FOR USE IN THE TREATMENT OF IL-1 RELATED DISEASES AND CONDITIONS
摘要 The present invention relates to a peptide, more particularly to a peptide comprising D-amino acids, and compositions containing the peptide, which are suitable for the treatment of IL-related diseases and conditions.
申请公布号 US2017022258(A1) 申请公布日期 2017.01.26
申请号 US201214239871 申请日期 2012.08.21
申请人 PASPALIARIS Vasilis;LANGAN Brett 发明人 PASPALIARIS Vasilis;LANGAN Brett
分类号 C07K14/54 主分类号 C07K14/54
代理机构 代理人
主权项 1. A peptide comprising the sequence of general formula (I):(I)(SEQ ID NO: 1)Z1-X20-DX1-DX2-DX3-DX4-DX5-DX6-DX7-DX8-DX9-DX10-DX11-DX12-DX13-DX14-DX15-X21-Z2 or salts, solvates, derivatives, isomers or tautomers thereof, wherein X1 is DLeu, DVal or DIle; X2 is DPro or Aze; X3 is DLeu, DVal or DIle; X4 is DAla or DGly; X5 is DTyr, DTrp, DPhe or DHis; X6 is DPro or Aze; X7 is DGln, DSer, DThr, DMet, DCys or DAsn; X8 is DTrp, DTyr, DPhe or DHis; X9 is DTyr, DTrp, DPhe or DHis; X10 is DGly or DAla; X11 is DPro or Aze; X12 is DThr, DGln, DSer, DMet, DCys or DAsn; X13 is DTrp, DTyr, DPhe or DHis; X14 is DGIU or DAsp; X15 is DPhe, DTyr, DTrp or DHis; X20 and X21 are each independently absent or one or more amino acids; and Z1 and Z2 are each independently absent or a protecting group.
地址 Victoria AU