| 发明名称 |
QUINOLONE-3-DIARYLETHERS |
| 摘要 |
Disclosed are derivative compounds of ELQ-300 that include an ester at position 4. These compounds have enhanced properties relative to ELQ-300. Also disclosed are pharmaceutical compositions comprising the compounds and methods of treating and preventing malaria infections involving administering the pharmaceutical compositions to the subject. |
| 申请公布号 |
US2017022164(A1) |
申请公布日期 |
2017.01.26 |
| 申请号 |
US201615215103 |
申请日期 |
2016.07.20 |
| 申请人 |
OREGON HEALTH & SCIENCE UNIVERSITY ;THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS |
发明人 |
Riscoe Michael;Nilsen Aaron;Stickles Allison;Miley Galen;Winter Rolf;Pou Sovitj;Li Yuexin;Kelly Jane Xu;Forquer Isaac;Doggett J. Stone;Bruzual Igor;Frueh Lisa;Dodean Rozalia;Smilkstein Martin;Alday Holland;Koop Dennis;Bleyle Lisa |
| 分类号 |
C07D215/22;C07D409/12;C07D405/12 |
主分类号 |
C07D215/22 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound with of the following structure, or any pharmaceutically active salt thereof: where X is halo and R is an ester or any pharmaceutically active salt thereof. |
| 地址 |
Portland OR US |
