IDENTIFICATION OF BLOOD BASED METABOLITE BIOMARKERS OF PANCREATIC CANCER

摘要

The present disclosure relates to a panel of a plurality of metabolite species that is useful for the identification or detection of subjects having pancreatic cancer, including methods for identifying such metabolic biomarkers within biological samples. The disclosure also includes a statistical model for predicting the presence of pancreatic cancer in a subject's biofluid by quantifying and comparing positive and negative fold changes in metabolite species' concentration; comparing the subject's metabolite species' concentrations to a predetermined value.

主权项

1. A method for detecting pancreatic cancer in a subject, comprising:
establishing a training dataset based on measured concentrations of at least two metabolite species based on known pancreatic cancer data, wherein the at least two metabolite species is a component of a panel of a plurality of metabolite species; measuring concentrations of the at least two metabolite species in a sample of a biofluid from a subject; comparing the measured concentration of the at least two metabolite species to the training dataset based on combined regression and univariate analysis, thereby generating a score; and comparing the score to a score of healthy group in order to predict presence of pancreatic cancer in the subject.