发明名称 |
NOVEL ALLOSTERIC INHIBITORS OF PROTEASOME AND METHODS OF USE THEREOF |
摘要 |
The present invention relates generally to novel allosteric regulators of proteasome activity, methods for preparation and use, and pharmaceutical compositions thereof. Specifically piperidine-2-carboxylic acid derivatives containing 1-oxo-aroyl group and a lipophilic ester side chain are disclosed as allosteric inhibitors of proteasome 2S activity, and as therapeutic agents for the treatment of proteasome-associated disorders in a subject. |
申请公布号 |
EP3007696(A4) |
申请公布日期 |
2017.01.25 |
申请号 |
EP20140811064 |
申请日期 |
2014.06.13 |
申请人 |
The Board of Regents of The University of Texas System |
发明人 |
OSMULSKI, Pawel, A.;GACZYNSKA, Maria, E. |
分类号 |
A61K31/445;A01N43/34;C07D211/00 |
主分类号 |
A61K31/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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