发明名称 |
RNA SYNTHESIS - PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION, AND APPLICATION IN CONVENIENT INTRODUCTION OF LIGANDS, CHROMOPHORES AND MODIFICATIONS OF SYNTHETIC RNA AT THE 3' - END |
摘要 |
The present invention relates to novel phosphoramidites, A-n-bz, C-n-bz, C-n-ac, G-n-ac and U are produced with an HPLC purity of greater than 98% and 31P NMR purity greater than 99%. A novel process of reverse 5′→3′ directed synthesis of RNA oligomers has been developed and disclosed. Using that method demonstrated high quality RNA synthesis with coupling efficiency approaching 99%. |
申请公布号 |
EP2326656(B1) |
申请公布日期 |
2017.01.25 |
申请号 |
EP20090789283 |
申请日期 |
2009.09.08 |
申请人 |
Chemgenes Corporation |
发明人 |
SRIVASTAVA, Suresh, C.;PANDEY, Divya;SRIVASTAVA, Naveen, P.;BAJPAI, Satya, P. |
分类号 |
C07H19/067;C07H1/00;C07H19/167;C07H21/02;C12N15/113 |
主分类号 |
C07H19/067 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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